As most cyclists and other travellers know, the only real gap in the Panamericana is the borderzone between Panama & Colombia, called the Darien Gap.
Physically there simply is no road (there seem to be some tracks), and a lot of jungle. Politically it is a dangerous mess with guerillas and drugs kartels on both sides, so not really recommended anyway.
Though some people have crossed over land, read the crazy story of Karl Bushby (Odyssey XXI)’s crossing and his reflection before you attempt it. The Riding the Spine BikeTravellers did it in canoo’s, which sounds more fun than it apparently was (hats off though!).
There are basically two ways to cross safely, read the full stories and tips from other Panam-riders on:
http://panamriders.biketravellers.com/crossing-from-panama-cartagena-by-boat-plane-experiences-from-biketravellers/
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